Anogenital Human Papillomavirus and HIV Infection in Rwandan Men Who Have Sex with Men

Authors

Gad Murenzi, Rwanda Military Hospital, Kigali, Rwanda
Hae-Young Kim, New York Medical College, Valhalla, NYFollow
Joel Palefsky, University of California San Francisco, San Francisco, CA

Additional Author Affiliation

New York Medical College

Author ORCID Identifier

0000-0001-7916-6625

DOI

10.1097/QAI.0000000000002376

Journal Title

Journal of Acquired Immune Deficiency Syndromes

Document Type

Article

Publication Date

8-2020

Department

Public Health

Abstract

Background:

Men who have sex with men (MSM) have a high prevalence of anal and penile human papillomavirus (HPV) infections with MSM living with HIV (MSMLH) bearing the highest rates. Data on anogenital high-risk HPV (hrHPV) among MSM in Rwanda and the associated risk factors are scant.

Methods:

We recruited 350 self-identified MSM aged 18 years living in Kigali, Rwanda, with 300 recruited from the community and 50 from partner clinics. Anal and penile specimens from all participants were analyzed for hrHPV using the AmpFire platform. Logistic regression was used to calculate crude odds ratios (ORs) and adjusted ORs (aORs) with 95% confidence intervals (95% CIs) as a measure of association between various factors and anal and penile hrHPV infection prevalence.

Results:

Anal hrHPV prevalence was 20.1%, was positively associated with having receptive anal sex with more partners (aOR: 9.21, 95% CI: 3.66 to 23.14), and was negatively associated with having insertive anal sex with more partners (aOR: 0.28, 95% CI: 0.12 to 0.66). Penile hrHPV prevalence was 35.0%, was negatively associated with having receptive anal sex with more partners (aOR: 0.29, 95% CI: 0.13 to 0.66), and differed significantly by HIV status, with 55.2% and 29.7% for MSMLH and HIV-negative MSM, respectively (P < 0.01).

Conclusion:

Penile hrHPV prevalence was higher than that of anal hrHPV and it was significantly higher in Rwandan MSMLH than in HIV-negative MSM. The prevalence of anal and penile HPV infections is likely variable at different locations in Africa, according to a number of factors including HIV status and sexual practices.

Comments

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Recommended Citation

Murenzi G., Kim H.-Y., Munyaneza A., Tuyisenge P., Zawadi T., Buteera A., Adedimeji A., Mutesa L., Castle P.E., Anastos K., Palefsky J.M. Anogenital Human Papillomavirus and HIV Infection in Rwandan Men Who Have Sex with Men. Journal of Acquired Immune Deficiency Syndromes 84(5):463-469 (2020).