COVID-19: Understanding the Science of Antibody Testing and Lessons from the HIV Epidemic

Authors

Stanley H. Weiss
Gary P. Wormser, New York Medical CollegeFollow

DOI

10.1016/j.diagmicrobio.2020.115078

Journal Title

Diagnostic Microbiology and Infectious Disease

First Page

115078

Last Page

115078

Document Type

Article

Publication Date

9-1-2020

Department

Medicine

Keywords

Antibodies, Viral, Betacoronavirus, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Coronavirus Infections, HIV Infections, Humans, Pandemics, Pneumonia, Viral, SARS-CoV-2, Sensitivity and Specificity, United States, United States Food and Drug Administration

Disciplines

Diagnosis | Infectious Disease | Medicine and Health Sciences | Virus Diseases

Abstract

Potential pitfalls in the development, deployment and interpretation of antibody tests for COVID-19 are discussed. Lessons learned from the experience with the introduction of antibody tests for HIV are highlighted.Each test will need to be separately vetted for performance and clinical implementation based upon rigorous clinical trial data. The issues we highlight will also be similarly important for vaccine and therapeutic drug efficacy trials.

Recommended Citation

Weiss, S. H., & Wormser, G. P. (2020). COVID-19: Understanding the Science of Antibody Testing and Lessons from the HIV Epidemic. Diagnostic Microbiology and Infectious Disease, 98 (1), 115078-115078. https://doi.org/10.1016/j.diagmicrobio.2020.115078