NYMC Faculty Publications
Dietary Glycaemic Index, Glycaemic Load and Head and Neck Cancer Risk: A Pooled Analysis in an International Consortium
DOI
10.1038/s41416-019-0702-4
Journal Title
British Journal of Cancer
First Page
745
Last Page
748
Document Type
Article
Publication Date
3-2020
Department
Otolaryngology
Keywords
Case-Control Studies, Female, Glycemic Index, Glycemic Load, Head and Neck Neoplasms, Humans, Male, Surveys and Questionnaires
Disciplines
Medicine and Health Sciences
Abstract
High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.
Recommended Citation
Chang, C., Yu, G., & Edefonti, V. (2020). Dietary Glycaemic Index, Glycaemic Load and Head and Neck Cancer Risk: A Pooled Analysis in an International Consortium. British Journal of Cancer, 122 (6), 745-748. https://doi.org/10.1038/s41416-019-0702-4
Comments
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