NYMC Faculty Publications
Idiopathic T Cell Lymphopenia Identified in New York State Newborn Screening
DOI
10.1016/j.clim.2017.07.002
Journal Title
Clinical Immunology (Orlando, Fla.)
First Page
36
Last Page
40
Document Type
Article
Publication Date
July 2017
Department
Pediatrics
Abstract
Quantification of T-cell receptor excision circles (TRECs) for newborn screening for SCID has advanced the diagnosis of severe combined immune deficiency (SCID). However, it has led to the identification of infants with T cell lymphopenia without known cause. The clinical characteristics, appropriate laboratory monitoring, and outcomes of patients remain unclear. We performed a retrospective review of clinical and laboratory studies for 26 infants collected from 7 New York State referral centers from 2010 to 2016 with low TRECs (mean, 70copies/mul) and subnormal CD3 counts (mean, 1150/cubicmm). Over time absolute CD3 counts increased in 17 and decreased in 9; 22 (85%) have done well clinically regardless of absolute T cell values. Additional infants with TCL will continue to be identified in newborn screening panels. While most patients seem to do well clinically, parameters for diagnosis and monitoring have yet to be formalized, and additional information needs to be collected, causes and outcomes reported.
Recommended Citation
Albin-Leeds, S., Ochoa, J., Mehta, H., Vogel, B., Caggana, M., Bonagura, V., Lehman, H., Ballow, M., Rubinstein, A., Siegel, S., Weiner, L., Weinberg, G., & Cunningham-Rundles, C. (2017). Idiopathic T Cell Lymphopenia Identified in New York State Newborn Screening. Clinical Immunology (Orlando, Fla.), 183, 36-40. https://doi.org/10.1016/j.clim.2017.07.002
