Cardiovascular Sequelae of Sickle Cell Disease

Authors

Amandeep Aujla, New York Medical CollegeFollow
Dibyendu Dutta, New York Medical CollegeFollow
Salomon Amar, New York Medical CollegeFollow
William Frishman, New York Medical CollegeFollow
Seah H. Lim, New York Medical CollegeFollow

DOI

10.1097/CRD.0000000000000264

Journal Title

Cardiology in Review

First Page

10

Last Page

13

Document Type

Article

Publication Date

1-1-2020

Department

Pharmacology

Second Department

Medicine

Abstract

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies worldwide. It is a multisystem disease that causes considerable patient morbidity. Despite advances in medical treatment, cardiopulmonary complications remain the most common cause of death in individuals with SCD. A growing body of evidence has shown that SCD results in a spectrum of cardiovascular complications through a variety of mechanisms, including chronic hemolysis, local tissue hypoxia, increased oxidative stress, and autonomic instability. Herein, we will examine the pathophysiology of sickle cell vasculopathy and discuss the spectrum of cardiovascular sequelae of the disease, while highlighting the impact of SCD on the cardiovascular health of the patients.

Recommended Citation

Aujla, A., Dutta, D., Amar, S., Frishman, W., & Lim, S. H. (2020). Cardiovascular Sequelae of Sickle Cell Disease. Cardiology in Review, 28 (1), 10-13. https://doi.org/10.1097/CRD.0000000000000264