NYMC Faculty Publications
L-Arginine-Nitric Oxide-Asymmetric Dimethylarginine Pathway and the Coronary Circulation: Translation of Basic Science Results to Clinical Practice
DOI
10.3389/fphar.2020.569914
Journal Title
Frontiers in Pharmacology
First Page
569914
Last Page
569914
Document Type
Article
Publication Date
9-29-2020
Department
Physiology
Keywords
L-arginine, asymmetric dimethylarginine (ADMA), coronary artery disease, coronary revascularization, ischemia/reperfusion, nitric oxide (NO), pericardial fluid
Disciplines
Cardiology | Medical Physiology | Medicine and Health Sciences
Abstract
By 1980, it was thought that we already knew most of the major mechanisms regulating vascular tone. However, after the somewhat serendipity discovery that endothelium is involved in mediation of relaxation to acetylcholine, a whole new world opened up and we had to rewrite our concept regarding vascular function and its regulation (not to mention many other fields). The new player was an endothelium derived relaxing factor, which molecular constitution has been identified to be nitric oxide (NO). This review summarizes the major molecular steps concerning how NO is synthetized from L-arginine. Also, the fate of L-arginine is described
Recommended Citation
Cziráki, A., Lenkey, Z., Sulyok, E., Szokodi, I., & Koller, A. (2020). L-Arginine-Nitric Oxide-Asymmetric Dimethylarginine Pathway and the Coronary Circulation: Translation of Basic Science Results to Clinical Practice. Frontiers in Pharmacology, 11, 569914-569914. https://doi.org/10.3389/fphar.2020.569914
