The Contribution of Chymase-Dependent Formation of ANG II to Cardiac Dysfunction in Metabolic Syndrome of Young Rats: Roles of Fructose and EETs

Authors

Ghezal Froogh
Sharath Kandhi, New York Medical CollegeFollow
Sharath Kandhi
Roopa Duvvi
Yicong Le
Zan Weng
Norah AlruwailiFollow
Jonathan O. Ashe
Dong Sun, New York Medical CollegeFollow
An Huang, New York Medical CollegeFollow

DOI

10.1152/ajpheart.00633.2019

Journal Title

American Journal of Physiology. Heart and Circulatory Physiology

First Page

985

Last Page

993

Document Type

Article

Publication Date

4-1-2020

Department

Physiology

Keywords

8, 11, 14-Eicosatrienoic Acid, Angiotensin II, Animals, Antioxidants, Cardiac Output, Cells, Cultured, Chymases, Enzyme Inhibitors, Epoxide Hydrolases, Fructose, Heart, Heart Diseases, Heart Rate, Male, Metabolic Syndrome, Myocardium, Oxidative Stress, Phenylurea Compounds, Piperidines, Rats, Rats, Sprague-Dawley

Disciplines

Medical Physiology | Medicine and Health Sciences

Abstract

The roles of ACE-independent ANG II production via chymase and therapeutic potential of epoxyeicosatrienoic acids (EETs) in fructose-induced metabolic syndrome (MetS) in the adolescent population remain elusive. Thus we tested the hypothesis that a high-fructose diet (HFD) in young rats elicits chymase-dependent increases in ANG II production and oxidative stress, responses that are reversible by 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-

Recommended Citation

Froogh, G., Kandhi, S., Kandhi, S., Duvvi, R., Le, Y., Weng, Z., Alruwaili, N., Ashe, J. O., Sun, D., & Huang, A. (2020). The Contribution of Chymase-Dependent Formation of ANG II to Cardiac Dysfunction in Metabolic Syndrome of Young Rats: Roles of Fructose and EETs. American Journal of Physiology. Heart and Circulatory Physiology, 318 (4), 985-993. https://doi.org/10.1152/ajpheart.00633.2019