NYMC Faculty Publications
The Contribution of Chymase-Dependent Formation of ANG II to Cardiac Dysfunction in Metabolic Syndrome of Young Rats: Roles of Fructose and EETs
Journal Title
American Journal of Physiology. Heart and Circulatory Physiology
First Page
985
Last Page
993
Document Type
Article
Publication Date
4-1-2020
Department
Physiology
Abstract
The roles of ACE-independent ANG II production via chymase and therapeutic potential of epoxyeicosatrienoic acids (EETs) in fructose-induced metabolic syndrome (MetS) in the adolescent population remain elusive. Thus we tested the hypothesis that a high-fructose diet (HFD) in young rats elicits chymase-dependent increases in ANG II production and oxidative stress, responses that are reversible by 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-
Recommended Citation
Froogh, G., Kandhi, S., Kandhi, S., Duvvi, R., Le, Y., Weng, Z., Alruwaili, N., Ashe, J. O., Sun, D., & Huang, A. (2020). The Contribution of Chymase-Dependent Formation of ANG II to Cardiac Dysfunction in Metabolic Syndrome of Young Rats: Roles of Fructose and EETs. American Journal of Physiology. Heart and Circulatory Physiology, 318 (4), 985-993. https://doi.org/10.1152/ajpheart.00633.2019
