NYMC Faculty Publications
Resveratrol Suppresses Prostate Cancer Epithelial Cell Scatter/Invasion by Targeting Inhibition of Hepatocyte Growth Factor (HGF) Secretion by Prostate Stromal Cells and Upregulation of E-cadherin by Prostate Cancer Epithelial Cells
DOI
10.3390/ijms21051760
Journal Title
International Journal of Molecular Sciences
First Page
1760
Document Type
Article
Publication Date
3-4-2020
Department
Biochemistry and Molecular Biology
Keywords
Antigens, CD, Cadherins, Cell Line, Tumor, Cell Movement, Culture Media, Conditioned, Epithelial Cells, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Hepatocyte Growth Factor, Humans, Male, Neoplasm Invasiveness, Phenotype, Prostate, Prostatic Neoplasms, Resveratrol, Signal Transduction, Stromal Cells, Transcriptional Activation
Disciplines
Medicine and Health Sciences
Abstract
Cancer mortality is primarily attributed to metastasis and the resulting compromise of organs secondary to the initial tumor site. Metastasis is a multi-step process in which the tumor cells must first acquire a migratory phenotype and invade through the surrounding tissue for spread to distant organs in the body. The ability of malignant cells to migrate and breach surrounding tissue/matrix barriers is among the most daunting challenges to disease management for men in the United States diagnosed with prostate cancer (CaP), especially since, at diagnosis, a high proportion of patients already have occult or clinically-detectable metastasis. The interaction between hepatocyte growth factor (HGF) secreted by the stroma, with its receptor c-Met located in the epithelium, must occur for epithelial CaP cells to become migratory. We studied the effects of grape-derived phytochemical resveratrol on the transition of epithelial tumor cells from sedentary to a mobile, penetrant phenotype. A time lapse microscopy assay was used to monitor the acquisition of the migratory phenotype by resveratrol. The results show that resveratrol inhibits HGF-mediated interaction between the stroma and epithelium and suppresses epithelial CaP cell migration by attenuating the control of epithelial-to-mesenchymal transition (EMT).
Recommended Citation
Hsieh, T., & Wu, J. M. (2020). Resveratrol Suppresses Prostate Cancer Epithelial Cell Scatter/Invasion by Targeting Inhibition of Hepatocyte Growth Factor (HGF) Secretion by Prostate Stromal Cells and Upregulation of E-cadherin by Prostate Cancer Epithelial Cells. International Journal of Molecular Sciences, 21 (5), 1760. https://doi.org/10.3390/ijms21051760