Retinoblastoma in Infancy with Subsequent Bladder Leiomyosarcoma in Adulthood: Genomic Considerations

Authors

Hovsep Ohan
Greg Minassian
Haig Minassian
Taliya Farooq, New York Medical CollegeFollow
Matthew J. Zdilla

Journal Title

Urology

First Page

38

Last Page

40

Document Type

Case Report

Publication Date

6-2020

Department

Pathology, Microbiology and Immunology

Abstract

Hereditary retinoblastoma is attributed to germline mutation in an RB1 tumor suppressor gene followed by somatic mutation in the other allele. This report details a case of leiomyosarcoma of the bladder in a 24-year-old man with a history of retinoblastoma treated by enucleation and radiotherapy in infancy. Leiomyosarcoma is the most common secondary soft tissue malignancy in retinoblastoma survivors; however, leiomyosarcoma of the bladder in retinoblastoma survivors is very rare. Survivors of hereditary retinoblastoma should be monitored closely for secondary malignancies, and there should be an increased suspicion of malignancy. Furthermore, tumors can occur outside the field of radiation.

Recommended Citation

Ohan, H., Minassian, G., Minassian, H., Farooq, T., & Zdilla, M. J. (2020). Retinoblastoma in Infancy with Subsequent Bladder Leiomyosarcoma in Adulthood: Genomic Considerations. Urology, 140, 38-40. https://doi.org/10.1016/j.urology.2020.03.010