NYMC Faculty Publications
Firth Adjustment for Weibull Current-Status Survival Analysis
DOI
10.1080/03610926.2019.1606241
Journal Title
Communications in Statistics
First Page
4587
Last Page
4602
Document Type
Article
Publication Date
2020
Department
Biostatistics
Abstract
Analysis of right-censored data is problematic due to infinite maximum likelihood estimates (MLE) and potentially biased estimates, especially for small numbers of events. Analyzing current-status data is especially troublesome because of the extreme loss of precision due to large failure intervals. We extend Firth’s method for regular parametric problems to current-status modeling with the Weibull distribution. Firth advocated a bias reduction method for MLE by systematically correcting the score equation. An advantage is that it is still applicable when the MLE does not exist. We present simulation studies and two illustrative analyses involving RFM mice lung tumor data.
Recommended Citation
Lin, H., Williamson, J. M., & Kim, H. (2020). Firth Adjustment for Weibull Current-Status Survival Analysis. Communications in Statistics, 49 (18), 4587-4602. https://doi.org/10.1080/03610926.2019.1606241