NYMC Faculty Publications
Augmented Graphene Quantum Dot-Light Irradiation Therapy for Bacteria-Infected Wounds
DOI
10.1021/acsami.0c13237
Journal Title
ACS Applied Materials and Interfaces
First Page
40153
Last Page
40162
Document Type
Article
Publication Date
9-9-2020
Department
Pathology, Microbiology and Immunology
Abstract
This paper proposes a highly efficient antibacterial system based on a synergistic combination of photodynamic therapy, photothermal therapy, and chemotherapy. Chitosan oligosaccharide functionalized graphene quantum dots (GQDs-COS) with short-term exposure to 450 nm visible light are used to promote rapid healing in bacteria-infected wounds. The GQDs undergo strong photochemical transformation to rapidly produce radical oxygen species and heat under light illumination, while the COS has an innate antimicrobial ability. Moreover, the positively charged GQDs-COS can easily capture bacteria via electrostatic interactions and kill Gram-positive and Gram-negative bacteria by multivalent interactions and synergistic effects. The antibacterial action of this nanocomposite causes irreversible damage to outer and inner bacterial membranes, resulting in cytoplasm leakage and death. The system has good hemocompatibility and low cytotoxicity and can improve the healing of infected wounds, as demonstrated by the examination of pathological tissue sections and inflammatory markers. These results suggest that GQDs anchored with bioactive molecules are a potential photo-activated antimicrobial strategy for anti-infective therapy.
Recommended Citation
Mei, L., Gao, X., Shi, Y., Cheng, C., Shi, Z., Jiao, M., Cao, F., Xu, Z., Li, X., & Zhang, J. (2020). Augmented Graphene Quantum Dot-Light Irradiation Therapy for Bacteria-Infected Wounds. ACS Applied Materials and Interfaces, 12 (36), 40153-40162. https://doi.org/10.1021/acsami.0c13237