NYMC Faculty Publications
Sclerosing Mesenteritis in a Patient Heterozygous for Factor V Leiden
DOI
10.12659/AJCR.926332
Journal Title
American Journal of Case Reports
First Page
926332
Last Page
926332
Document Type
Case Report
Publication Date
10-5-2020
Department
Surgery
Keywords
Factor V, Humans, Mesentery, Panniculitis, Peritoneal, Thrombophilia
Disciplines
Medicine and Health Sciences
Abstract
BACKGROUND Sclerosing mesenteritis is an inflammatory and fibrotic disease that affects the mesentery of the small intestine. This condition is non-neoplastic, although it is frequently associated with underlying malignancies. The overall etiology is unclear because of the limited number of cases available for review, yet a number of possible mechanisms have been described, including ischemia. Factor V (FV) Leiden is a hereditary condition causing hypercoagulability, thrombosis, and ischemia. Because ischemia is one of the proposed mechanisms for the fibrosis and sclerotic findings of sclerosing mesenteritis, this case explores a possible association between FV Leiden and sclerosing mesenteritis. CASE REPORT Herein, we describe a case of sclerosing mesenteritis in a patient heterozygous for FV Leiden, with a strong personal and family history of venous thromboembolism. This patient presented with acute worsening of chronic abdominal pain and was found to have a small bowel obstruction requiring acute surgical intervention. Imaging findings and pathologic examination of the ileum and mesentery conclusively diagnosed sclerosing mesenteritis. CONCLUSIONS This case serves to highlight a possible association between mesenteric ischemia secondary to chronic thrombotic activity and sclerosing mesenteritis. This patient's virgin abdomen and lack of additional risk factors for sclerosing mesenteritis make this case a unique presentation of the disorder. This case serves to update the literature at large, as only one prior case in a FV Leiden patient has been described, in which the patient had the additional risk factor of previous abdominal surgery.
Recommended Citation
Reddington, H., Ballinger, Z., Abghari, M., Modukuru, V., & Wallack, M. (2020). Sclerosing Mesenteritis in a Patient Heterozygous for Factor V Leiden. American Journal of Case Reports, 21, 926332-926332. https://doi.org/10.12659/AJCR.926332
