Effect of Statin Use on the Clinical Manifestations, Laboratory Test Results and Outcome of Lyme Neuroborreliosis

Authors

Katarina Ogrinc
Andrej Kastrin
Stanka Lotrič-Furlan
Petra Bogovič
Tereza Rojko
Tjaša Cerar-Kišek
Eva Ružić-Sabljić
Gary P. Wormser, New York Medical CollegeFollow
Franc Strle

DOI

10.3390/jcm9092995

Journal Title

Journal of Clinical Medicine

First Page

2995

Last Page

2995

Document Type

Article

Publication Date

9-16-2020

Department

Medicine

Abstract

Statins have anti-inflammatory and potentially antimicrobial activity, but whether they have a beneficial effect on the course of infectious diseases is controversial. In this study, we assessed the impact of pre-existing statin use on the course and outcome of Lyme neuroborreliosis manifested as meningoradiculitis (Bannwarth's syndrome). One hundred and twenty three consecutive patients with Bannwarth's syndrome, of whom 18 (14.6%) were being treated with statins, were included in the study. To assess the influence of statin use on the course and outcome of the disease, univariate and multivariable analyses were performed. No statistically significant association was found between statin pre-treatment and the clinical manifestations, laboratory test results, and outcome of Bannwarth's syndrome. In conclusion, pre-existing use of statins did not significantly impact either the clinical presentation or the outcome of Bannwarth's syndrome.

Recommended Citation

Ogrinc, K., Kastrin, A., Lotrič-Furlan, S., Bogovič, P., Rojko, T., Cerar-Kišek, T., Ružić-Sabljić, E., Wormser, G. P., & Strle, F. (2020). Effect of Statin Use on the Clinical Manifestations, Laboratory Test Results and Outcome of Lyme Neuroborreliosis. Journal of Clinical Medicine, 9 (9), 2995-2995. https://doi.org/10.3390/jcm9092995