NYMC Faculty Publications
Activation of NPY Receptor Subtype 1 by [D-His 26]NPY is Sufficient to Prevent Development of Anxiety and Depressive like Effects in the Single Prolonged Stress Rodent Model of PTSD
DOI
10.1016/j.npep.2019.102001
Journal Title
Neuropeptides
First Page
102001
Last Page
102001
Document Type
Article
Publication Date
4-1-2020
Department
Biochemistry and Molecular Biology
Abstract
The neuropeptide Y (NPY) system plays an important role in mediating resilience to the harmful effect of stress in post-traumatic stress disorder (PTSD). It can mediate its effects via several G-protein coupled receptors: Y1R, Y2R, Y4R and Y5R. To investigate the role of individual NPY receptors in the resilience effects of NPY to traumatic stress, intranasal infusion of either Y1R agonists [D-His26]NPY, [Leu31Pro34]NPY, Y2R agonist NPY (3-36) or NPY were administered to male Sprague-Dawley rats immediately following the last stressor of the single prolonged stress (SPS) protocol, a widely used PTSD animal model. After 7 or 14 days, effects of the treatments were measured on the elevated plus maze (EPM) for anxiety, in forced swim test (FST) for development of depressive-like or re-experiencing behavior, in social interaction (SI) test for impaired social behavior, and acoustic startle response (ASR) for hyperarousal. [D-His26]NPY, but not [Leu31Pro34]NPY nor NPY (3-36) Y2R, was effective in preventing the SPS-elicited development of anxiety. Y1R, but not Y2R agonists prevented development of depressive- feature on FST, with [D-His26]NPY superior to NPY. The results demonstrate that [D-His26]NPY was sufficient to prevent development of anxiety, social impairment and depressive symptoms, and has promise as an early intervention therapy following traumatic stress.
Recommended Citation
Nwokafor, C., Serova, L. I., Nahvi, R. J., McCloskey, J., & Sabban, E. L. (2020). Activation of NPY Receptor Subtype 1 by [D-His 26]NPY is Sufficient to Prevent Development of Anxiety and Depressive like Effects in the Single Prolonged Stress Rodent Model of PTSD. Neuropeptides, 80, 102001-102001. https://doi.org/10.1016/j.npep.2019.102001