NYMC Faculty Publications
Pathophysiology of Chronic Peripheral Ischemia: New Perspectives
Journal Title
Therapeutic Advances in Chronic Disease
First Page
2040622319894466
Last Page
2040622319894466
Document Type
Review Article
Publication Date
2-5-2020
Department
Medicine
Second Department
Pharmacology
Abstract
Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.
Recommended Citation
Signorelli, S., Vanella, L., Abraham, N. G., Scuto, S., Marino, E., & Rocic, P. (2020). Pathophysiology of Chronic Peripheral Ischemia: New Perspectives. Therapeutic Advances in Chronic Disease, 11, 2040622319894466-2040622319894466. https://doi.org/10.1177/2040622319894466
