Pathophysiology of Chronic Peripheral Ischemia: New Perspectives

Authors

Salvatore Santo Signorelli
Luca Vanella
Nader G. Abraham, New York Medical CollegeFollow
Salvatore Scuto
Elisa Marino
Petra Rocic, New York Medical CollegeFollow

DOI

10.1177/2040622319894466

Journal Title

Therapeutic Advances in Chronic Disease

First Page

2040622319894466

Last Page

2040622319894466

Document Type

Review Article

Publication Date

2-5-2020

Department

Medicine

Second Department

Pharmacology

Abstract

Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.

Recommended Citation

Signorelli, S., Vanella, L., Abraham, N. G., Scuto, S., Marino, E., & Rocic, P. (2020). Pathophysiology of Chronic Peripheral Ischemia: New Perspectives. Therapeutic Advances in Chronic Disease, 11, 2040622319894466-2040622319894466. https://doi.org/10.1177/2040622319894466