NYMC Faculty Publications

Title

Pathophysiology of Chronic Peripheral Ischemia: New Perspectives

First Page

2040622319894466

Last Page

2040622319894466

Document Type

Review Article

Publication Date

2-5-2020

Department

Medicine

Second Department

Pharmacology

Abstract

Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.

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