Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent

Authors

Hao Wu
Qiqi YeFollow
Dana Razzano
Oya Tugal, New York Medical College
Jeremy Rosenblum, New York Medical CollegeFollow
Tracey L. Weigel, New York Medical College
Minghao Zhong

DOI

10.1177/1093526620957219

Journal Title

Pediatric and Developmental Pathology

First Page

472

Last Page

475

Document Type

Case Report

Publication Date

11-2020

Department

Pediatrics

Second Department

Surgery

Abstract

Primary lung adenocarcinomas are rare in pediatric patients, and even rarer in patients without precedent malignancy or congenital malformation. Here we present the first reported case of primary lung cribriform adenocarcinoma with squamoid morules in a previously healthy adolescent female. Molecular testing identified CTNNB1 mutation in the tumor and excluded other common mutations in lung adenocarcinoma. Our case suggests molecular alterations to the same signaling pathway can lead to similar histomorphology regardless of the tissue of origin.

Recommended Citation

Wu, H., Ye, Q., Razzano, D., Tugal, O., Rosenblum, J., Weigel, T. L., & Zhong, M. (2020). Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent. Pediatric and Developmental Pathology, 23 (6), 472-475. https://doi.org/10.1177/1093526620957219