NYMC Faculty Publications
Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent
Journal Title
Pediatric and Developmental Pathology
First Page
472
Last Page
475
Document Type
Case Report
Publication Date
11-2020
Department
Pediatrics
Second Department
Surgery
Abstract
Primary lung adenocarcinomas are rare in pediatric patients, and even rarer in patients without precedent malignancy or congenital malformation. Here we present the first reported case of primary lung cribriform adenocarcinoma with squamoid morules in a previously healthy adolescent female. Molecular testing identified CTNNB1 mutation in the tumor and excluded other common mutations in lung adenocarcinoma. Our case suggests molecular alterations to the same signaling pathway can lead to similar histomorphology regardless of the tissue of origin.
Recommended Citation
Wu, H., Ye, Q., Razzano, D., Tugal, O., Rosenblum, J., Weigel, T. L., & Zhong, M. (2020). Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent. Pediatric and Developmental Pathology, 23 (6), 472-475. https://doi.org/10.1177/1093526620957219
