NYMC Faculty Publications

Doxycycline for Prevention of Spirochetal Infections: Status Report

DOI

10.1093/cid/ciaa240

Journal Title

Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America

First Page

2014

Last Page

2017

Document Type

Article

Publication Date

11-5-2020

Department

Medicine

Abstract

Important human infections caused by spirochetal microorganisms include Lyme disease, syphilis, leptospirosis, and tick-borne relapsing fever. Doxycycline prophylactic regimens have been shown to significantly reduce the risk for developing all of these infections in potentially exposed individuals, which is highly clinically relevant as no vaccines to prevent these infections in humans are currently available. Additional data, however, are needed to define more precisely the level of efficacy of the doxycycline prophylactic regimens, especially for Lyme disease and syphilis, infections that can be potentially prevented by a single 200-mg dose of doxycycline given within 72 hours postexposure.

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