NYMC Faculty Publications
Exclusive Human Milk Diet Reduces Incidence of Severe Intraventricular Hemorrhage in Extremely Low Birth Weight Infants
Author Type(s)
Faculty
Journal Title
Journal of Perinatology
First Page
535
Last Page
543
Document Type
Article
Publication Date
3-2021
Department
Pediatrics
Abstract
OBJECTIVE: Compare the incidence of severe (grade III/IV) intraventricular hemorrhage (IVH) and/or periventricular leukomalacia (PVL) between two groups of ELBW infants based on diet until 34 weeks corrected gestational age (CGA): (1) Exclusive human milk (EHM)-mother's own and/or pasteurized donor human milk, human milk-derived fortifier, and oral care with colostrum/human milk vs. (2) non-EHM-bovine formula or mother's own milk with bovine-derived fortifier.
STUDY DESIGN: Retrospective observational study of two groups of ELBW infants based on diet until 34 weeks CGA.
RESULT: There were n = 306 infants, 127 EHM and 179 non-EHM. Demographics and morbidities were similar except higher antenatal steroids and NEC in EHM group. The rate of severe IVH/PVL was lower in EHM compared to non-EHM group (7 vs. 18%, p < 0.006).
CONCLUSION: EHM diet had an independent neuroprotective effect and was associated with decreased incidence of severe IVH/PVL, supporting the need of EHM in ELBW infants.
Recommended Citation
Carome, K., Rahman, A., & Parvez, B. (2021). Exclusive Human Milk Diet Reduces Incidence of Severe Intraventricular Hemorrhage in Extremely Low Birth Weight Infants. Journal of Perinatology, 41 (3), 535-543. https://doi.org/10.1038/s41372-020-00834-5
