NYMC Faculty Publications

Hygromycin A in the Lymelight

Author Type(s)

Faculty

DOI

10.1016/j.chom.2021.10.007

Journal Title

Cell Host & Microbe

First Page

1599

Last Page

1601

Document Type

Response or Comment

Publication Date

11-10-2021

Department

Pathology, Microbiology and Immunology

Keywords

Borrelia burgdorferi, Borrelia burgdorferi Group, Cinnamates, Humans, Hygromycin B, Lyme Disease

Disciplines

Medicine and Health Sciences

Abstract

Lyme disease, which is caused by the spirochete Borrelia burgdorferi, is on the rise. Current treatment relies on broad-spectrum antibiotics that perturb the gut microbiome. In a recent paper in Cell, Leimer et al. demonstrate the utility of a long-forgotten antibiotic, Hygromycin A, as a spirochete-specific antibacterial that is conducive to gut health.

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