Hygromycin A in the Lymelight
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Pathology, Microbiology & Immunology
Lyme disease, which is caused by the spirochete Borrelia burgdorferi, is on the rise. Current treatment relies on broad-spectrum antibiotics that perturb the gut microbiome. In a recent paper in Cell, Leimer et al. demonstrate the utility of a long-forgotten antibiotic, Hygromycin A, as a spirochete-specific antibacterial that is conducive to gut health.
Arnaboldi, P. M., & Narasimhan, S. (2021). Hygromycin A in the Lymelight. Cell Host & Microbe, 29 (11), 1599-1601. https://doi.org/10.1016/j.chom.2021.10.007