NYMC Faculty Publications
Active Implantable Cardioverter-Defibrillators in Continuous-Flow Left Ventricular Assist Device Recipients
Author Type(s)
Faculty
Journal Title
Journal of Atrial Fibrillation
First Page
20200490
Last Page
20200490
Document Type
Article
Publication Date
6-30-2021
Department
Medicine
Abstract
INTRODUCTION: Implantable cardioverter-defibrillator (ICD) in patients with heart failure with reduced ejection fraction reduces mortality secondary to malignant arrhythmias. Whether end-stage heart failure (HF) with continuous-flow left ventricular assist device (cf-LVAD) derive similar benefits remains controversial.
METHODS: We performed a systematic literature review and meta-analysis of all published studies that examined the association between active ICDs and survival in advanced HF patients with cfLVAD. We searched PubMed, Medline, Embase, Ovid, and Cochrane for studies reporting the association between ICD and all-cause mortality in advanced HF patients with cfLVAD. Mantel-Haenszel risk ratio (RR) random-effects model was used to summarize data.
RESULTS: Ten studies (9 retrospective and one prospective) with a total of 7,091 patients met inclusion criteria. There was no difference in all-cause mortality (RR 0.84, 95% CI 0.65-1.10, p=0.20, I
CONCLUSIONS: All-cause mortality, the likelihood of survival to transplant, and worsening RV failure were not significantly different between active ICD and inactive/no ICD in cf-LVAD recipients. A substantial number of patients received appropriate ICD shocks suggesting a high-arrhythmia burden. The risks and benefits of ICDs must be carefully considered in patients with cf-LVAD.
Recommended Citation
Shah, K., Chaudhary, R., Turagam, M. K., Shah, M., Patel, B., Lanier, G., Lakkireddy, D., & Garg, J. (2021). Active Implantable Cardioverter-Defibrillators in Continuous-Flow Left Ventricular Assist Device Recipients. Journal of Atrial Fibrillation, 14 (1), 20200490-20200490. https://doi.org/10.4022/jafib.20200490
