NYMC Faculty Publications
Aggregation of Data from 4 Clinical Studies Demonstrating Efficacy of Single-Dose Doxycycline Postexposure for Prevention of the Spirochetal Infections: Lyme Disease, Syphilis, and Tick-Borne Relapsing Fever
Author Type(s)
Faculty
DOI
10.1016/j.diagmicrobio.2020.115293
Journal Title
Diagnostic Microbiology and Infectious Disease
First Page
115293
Last Page
115293
Document Type
Article
Publication Date
4-2021
Department
Medicine
Keywords
Anti-Bacterial Agents, Doxycycline, Humans, Lyme Disease, Post-Exposure Prophylaxis, Relapsing Fever, Syphilis
Disciplines
Medicine and Health Sciences
Abstract
Single-dose doxycycline, given within 72 hours of exposure, has been evaluated in 4 clinical studies for postexposure prophylaxis of 3 spirochetal infections: Lyme disease, syphilis, and tick-borne relapsing fever. In this study, data from the 4 studies were aggregated using a meta-analytic random-effects approach, with the DerSimonian-Laird method for variance estimation, analyzing a total of 2468 subjects. The findings of this analysis demonstrated an overall efficacy rate for prevention of the 3 spirochetal infections of 78% (95% confidence interval: 50%-91%).
Recommended Citation
Wormser, G. P., Warshafsky, S., & Visintainer, P. (2021). Aggregation of Data from 4 Clinical Studies Demonstrating Efficacy of Single-Dose Doxycycline Postexposure for Prevention of the Spirochetal Infections: Lyme Disease, Syphilis, and Tick-Borne Relapsing Fever. Diagnostic Microbiology and Infectious Disease, 99 (4), 115293-115293. https://doi.org/10.1016/j.diagmicrobio.2020.115293
