Prevalence and Temporal Trends of Anemia in Patients With Heart Failure

Authors

E U. Rahman, From the Department of Internal Medicine, St Mary's Medical Center, 2900 First Avenue, Huntington, WV 25702, USA.
M D. Chobufo, Department of Internal Medicine, Interfaith Medical Center, 1545 Atlantic Ave, Brooklyn, NY 11213, USA.Follow
F Farah, Department of Internal Medicine, Deccan College of Medical Sciences, DMRL X Road, Santosh Nagar Main Rd, Kanchan Bagh, Hyderabad, Telangana 500058, India.
T Mohamed, Department of Cardiology, Marshall University, 1 John Marshall dr, Huntington, WV 25755, USA.
M Elhamdani, Department of Cardiology, Marshall University, 1 John Marshall dr, Huntington, WV 25755, USA.
C Rueda, Department of Cardiology, Marshall University, 1 John Marshall dr, Huntington, WV 25755, USA.
W S. Aronow, Department of Cardiology research, Westchester Medical Centre and New York Medical College, 100 Woods Rd, Valhalla, NY 10595, USA.Follow
G C. Fonarow, Department of Cardiology, Ronald Reagan-UCLA Medical Center, 757 Westwood Plaza, Los Angeles, CA 90095, USA.
E Thompson, Department of Cardiology, Marshall University, 1 John Marshall dr, Huntington, WV 25755, USA.

Author Type(s)

Faculty

DOI

10.1093/qjmed/hcab193

Journal Title

QJM: Monthly Journal of the Association of Physicians

First Page

437

Last Page

441

Document Type

Article

Publication Date

7-9-2022

Department

Medicine

Abstract

BACKGROUND: Anemia is an important comorbidity in heart failure (HF), and it is associated with increased adverse disease experience and mortality. Previous reports have focused mainly on HF presenting in healthcare settings. We, therefore, set out to establish the nationwide prevalence and temporal trends of anemia in community-based patients with HF in the US. AIM: To establish the nationwide prevalence and temporal trends of anemia in community-based patients with HF in the US. DESIGN: The NHANES dataset, conducted by the CDC National Center for Health Statistics was used to collect nationally representative data on the health and nutritional status of the non-institutionalized US population. METHODS: We utilized the National Health and Nutrition Examination data collected over five survey cycles (2007-16). Included were participants aged 20-80 years with self-reported diagnosis of HF. Anemia was defined using 2 sex specific cut offs of 13 and 12 g/dl (cutoff 1), and 12 and 11 g/dl (cutoff 2), for men and women, respectively. The Chi square test was used to compare prevalence across different categories and survey cycles. Data analysis was done using STATA 16 with P-values < 0.05 considered statistically significant. RESULTS: The median hemoglobin in all HF patients was 13.5 g/dl (IQR 12.4-14.5). The prevalence of anemia among community-based patients with HF in the US was 21.34% (cutoff 1) and 9.03% (cutoff 2) and has been stable from 2007 to 2016. The burden of anemia was disproportionately higher in NH Blacks (34.48%, 95% CI 27.12-42.67) and those with BMI < 25 Kg/m2 (17.4%, 95% CI 10.9-26.64). CONCLUSION: The prevalence of anemia in patients with HF in the US is at least 9% and has remained stable over the past decade. This high persistent burden with limited proven interventions should spur further efforts aimed at identifying impactful ways of addressing anemia in patients with HF.

Recommended Citation

Rahman, E. U., Chobufo, M. D., Farah, F., Mohamed, T., Elhamdani, M., Rueda, C., Aronow, W. S., Fonarow, G. C., & Thompson, E. (2022). Prevalence and Temporal Trends of Anemia in Patients With Heart Failure. QJM: Monthly Journal of the Association of Physicians, 115 (7), 437-441. https://doi.org/10.1093/qjmed/hcab193