NYMC Faculty Publications

Eosinophilic Myocarditis: When Allergies Attack the Heart!

Vardhmaan Jain, From the Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH.Follow
Agam Bansal, From the Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH.
Devika Aggarwal, Department of Internal Medicine, Beaumont Hospital, Royal Oak, MI.Follow
Michael Chetrit, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH.
Manasvi Gupta, Department of Internal Medicine, University of Connecticut Health, Farmington, CT.Follow
Kirtipal Bhatia, Department of Internal Medicine, St. Luke Roosevelt Medical Centre/Mount Sinai, New York, NY.
Samarthkumar Thakkar, Department of Internal Medicine, Rochester General Hospital, Rochester, NY.
Rajkumar Doshi, Department of Internal Medicine, University of Nevada Reno School of Medicine, Reno, NV.
Raktim Ghosh, Department of Cardiovascular Medicine, Medstar Heart and Vascular Institute, Baltimore, MD.
Dhrubajyoti Bandopadhyay, Department of Internal Medicine, St. Luke Roosevelt Medical Centre/Mount Sinai, New York, NY.
Benico Barzilai, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH.
Carolyn Jane Shiau, Department of Pathology, Royal Columbian Hospital, New Westminster, BC, Canada.
William H. Frishman, Department of Medicine and Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.Follow
Wilbert S. Aronow, Department of Medicine and Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.Follow

Author Type(s)

Faculty

DOI

10.1097/CRD.0000000000000373

Journal Title

Cardiology in Review

First Page

70

Last Page

74

Document Type

Article

Publication Date

3-1-2022

Department

Medicine

Abstract

Eosinophilic myocarditis is a clinical condition whereby myocardial injury is mediated by eosinophilic infiltration. A number of underlying causes, including reactive, clonal, or idiopathic hypereosinophilic syndrome, may trigger eosinophilia. Disease presentation may vary from mild subclinical variants to fulminant myocarditis with thromboembolic complications, and in some cases, endomyocardial and valvular fibrosis may be seen. A detailed examination coupled with the use of multimodality imaging, and endomyocardial biopsy may help establish diagnosis. Treatment is aimed at symptomatic management and treating the underlying cause of eosinophilia, such as withdrawal of implicated drugs, antihelminthic therapy for infection, immunosuppression for autoimmune conditions, and targeted therapy with tyrosine kinase inhibitors in cases with clonal myeloid disorders.

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