NYMC Faculty Publications
Multisystem Inflammatory Syndrome in Children
Author Type(s)
Faculty
DOI
10.1016/j.jemermed.2021.07.070
Journal Title
The Journal of Emergency Medicine
First Page
28
Last Page
37
Document Type
Article
Publication Date
1-1-2022
Department
Emergency Medicine
Abstract
BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized condition affecting children with recent infection or exposure to coronavirus disease 2019 (COVID-19). MIS-C has symptoms that affect multiple organs systems, with some clinical features resembling Kawasaki disease (KD) and toxic shock syndrome (TSS). OBJECTIVE OF THE REVIEW: Our goal was to review the current literature and describe the evaluation and treatment algorithms for children suspected of having MIS-C who present to the emergency department. DISCUSSION: MIS-C has a wide clinical spectrum and diagnosis is based on a combination of both clinical and laboratory findings. The exact mechanism of immune dysregulation of MIS-C is not well understood. Physical findings may evolve and do not necessarily appear at the same time. Gastrointestinal, cardiac, inflammatory, and coagulopathy manifestations and dysfunction are seen frequently in MIS-C. CONCLUSIONS: The diagnosis of MIS-C is based on clinical presentation and specific laboratory findings. In the emergency setting, a high level of suspicion for MIS-C is required in patients exposed to COVID-19. Early diagnosis and prompt initiation of therapy offer the best chance for optimal outcomes.
Recommended Citation
Waseem, M., Shariff, M. A., Tay, E. T., Mortel, D., Savadkar, S., Lee, H., Kondamudi, N., & Liang, T. (2022). Multisystem Inflammatory Syndrome in Children. The Journal of Emergency Medicine, 62 (1), 28-37. https://doi.org/10.1016/j.jemermed.2021.07.070