The Year That Shaped the Outcome of the Ospa Vaccine for Human Lyme Disease

Authors

Raymond J. Dattwyler, Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA. Raymond_Dattwyler@nymc.edu.Follow
Maria Gomes-Solecki, Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA. mgomesso@uthsc.edu.

Author Type(s)

Faculty

DOI

10.1038/s41541-022-00429-5

Journal Title

NPJ Vaccines

First Page

10

Document Type

Article

Publication Date

1-27-2022

Department

Pathology, Microbiology and Immunology

Abstract

The expansion of Lyme borreliosis endemic areas and the corresponding increase of disease incidence have opened the possibility for greater acceptance of a vaccine. In this perspective article, we discuss the discovery of outer surface protein A (OspA) of B. burgdorferi, and the subsequent pre-clinical testing and clinical trials of a recombinant OspA vaccine for human Lyme disease. We also discuss in detail the open public hearings of the FDA Lyme disease vaccine advisory panel held in 1998 where concerns of molecular mimicry induced autoimmunity to native OspA were raised, the limitations of those studies, and the current modifications of recombinant OspA to develop a multivalent subunit vaccine for Lyme disease.

Recommended Citation

Dattwyler, R. J., & Gomes-Solecki, M. (2022). The Year That Shaped the Outcome of the Ospa Vaccine for Human Lyme Disease. NPJ Vaccines, 7 (1), 10. https://doi.org/10.1038/s41541-022-00429-5