The Clinical Impact of the Covid-19 Pandemic First Wave on Patients With Cystic Fibrosis in New York

Authors

Joseph L. Simonson, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: jsimonson2@northwell.edu.
Christine Esposito, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: cesposito5@northwell.edu.
Theresa Frantzen, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: tfrantzen1@northwell.edu.
Katherine Henthorne, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: khenthorne@northwell.edu.
Aileen Espinal, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: aespinal2@northwell.edu.
Serena Romano, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: sromano1@northwell.edu.
Ramona Ramdeo, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: rramdeo@northwell.edu.
Jessica Trentacoste, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: jkosiorek@northwell.edu.
Donna Tsang, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: dtsang@northwell.edu.
Geralyn LaVecchia, Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: glavecch@northwell.edu.
Robert Abdullah, Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: robert.abdullah@stonybrookmedicine.edu.
Maria Berdella, Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, United States. Electronic address: maria.berdella@mountsinai.org.
Lynn Bonitz, Division of Pediatric Pulmonology, The Steven and Alexandra Cohen Children's Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY 11042, United States. Electronic address: lbonitz@northwell.edu.
Rany Condos, Division of Pulmonary, Critical Care, and Sleep Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: rany.condos@nyulangone.org.
Andrei Constantinescu, Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: ac726@cumc.columbia.edu.
Joan K. DeCelie-Germana, Division of Pediatric Pulmonology, The Steven and Alexandra Cohen Children's Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY 11042, United States. Electronic address: jgermana@northwell.edu.
Emily DiMango, Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: ead3@cumc.columbia.edu.
Myah Draine, Division of Pulmonary, Critical Care, and Sleep Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: myah.draine@nyulangone.org.
Tara Gimeli, Division of Pediatric Pulmonology, The Steven and Alexandra Cohen Children's Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY 11042, United States. Electronic address: tgimeli@northwell.edu.
Robert Giusti, Division of Pediatric Pulmonary Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: robert.giusti@nyulangone.org.
Jessenia Guzman, Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: jmg2333@cumc.columbia.edu.
Soumia Hammouda, Division of Pediatric Pulmonary Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: soumia.hammouda@nyulangone.org.
Claire Keating, Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: ck2132@cumc.columbia.edu.
Catherine Kier, Department of Pediatrics, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: catherine.kier@stonybrookmedicine.edu.
Alison T. Lennox, Division of Pediatric Pulmonology, Allergy, Immunology, and Sleep Medicine, New York Medical College, Valhalla, NY 10595, United States. Electronic address: crl58@cumc.columbia.edu.
Carmen Liriano, Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: zachary_messser@nymc.edu.
Zachary Messer, Division of Pediatric Pulmonology, Allergy, Immunology, and Sleep Medicine, New York Medical College, Valhalla, NY 10595, United States. Electronic address: alennox@nymc.edu.
Amy Plachta, Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, United States. Electronic address: amy.plachta@mountsinai.org.
Hossein Sadeghi, Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: hs762@cumc.columbia.edu.
Elinor Schwind, Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, United States. Electronic address: elinor.schwind@mountsinai.org.
Teresa Stables-Carney, Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: teresa.stables-carney@stonybrookmedicine.edu.
Patricia Walker

Author Type(s)

Faculty

Journal Title

Journal of Cystic Fibrosis

First Page

e176

Last Page

e183

Document Type

Article

Publication Date

5-1-2022

Department

Pediatrics

Abstract

BACKGROUND: People with cystic fibrosis (pwCF) may be at risk of complications from COVID-19 but the impact of COVID-19 on pwCF remains unknown. METHODS: We conducted a multicenter retrospective cohort study to assess the impact of the COVID-19 pandemic first wave on pwCF in the New York metropolitan area (NY) from March 1, 2020 to August 31, 2020. Objectives were to determine (1) the prevalence of COVID-19 by PCR and IgG antibody testing, (2) the clinical characteristics of COVID-19, (3) delay in routine outpatient care, and (4) the effect on anxiety and depression in pwCF. RESULTS: There were 26 COVID-19 cases diagnosed by PCR or antibody testing among the study cohort of 810 pwCF. The prevalence of COVID-19 by PCR (1.6%) and IgG antibody (12.2%) testing was low. 58% of cases were asymptomatic and 82% were managed at home. 8% were hospitalized and 1 person died. 89% of pwCF experienced delay in care. The prevalence of anxiety increased from 43% baseline to 58% during the pandemic (P<0.01). In post-hoc analysis, the proportion of patients with diabetes (38% versus 16%, P<0.01) and pancreatic insufficiency (96% versus 66%, P<0.01) were higher while CFTR modulator use was lower (46% versus 65%, P = 0.05) in pwCF who tested positive for COVID-19. CONCLUSIONS: The prevalence of COVID-19 among pwCF in NY during the pandemic first wave was low and most cases were managed at home. CFTR modulators may be protective. PwCF experienced delay in routine care and increased anxiety.

Recommended Citation

Simonson, J. L., Esposito, C., Frantzen, T., Henthorne, K., Espinal, A., Romano, S., Ramdeo, R., Trentacoste, J., Tsang, D., LaVecchia, G., Abdullah, R., Berdella, M., Bonitz, L., Condos, R., Constantinescu, A., DeCelie-Germana, J. K., DiMango, E., Draine, M., Gimeli, T., Giusti, R., Guzman, J., Hammouda, S., Keating, C., Kier, C., Lennox, A. T., Liriano, C., Messer, Z., Plachta, A., Sadeghi, H., Schwind, E., Stables-Carney, T., & Walker, P. (2022). The Clinical Impact of the Covid-19 Pandemic First Wave on Patients With Cystic Fibrosis in New York. Journal of Cystic Fibrosis, 21 (3), e176-e183. https://doi.org/10.1016/j.jcf.2022.02.012