NYMC Faculty Publications
Olanzapine-Samidorphan Combination Tablets for the Treatment of Schizophrenia and Bipolar I Disorder - What Is It, and Will It Be Used?
Author Type(s)
Faculty
DOI
10.1080/14737175.2022.2060742
Journal Title
Expert Review of Neurotherapeutics
First Page
365
Last Page
376
Document Type
Article
Publication Date
5-1-2022
Department
Psychiatry and Behavioral Sciences
Abstract
INTRODUCTION: Although olanzapine remains one of the most efficacious antipsychotic medications for the treatment of schizophrenia, there are significant tolerability concerns related to its weight and metabolic profile. Olanzapine-samidorphan combination tablets (OLZ/SAM), branded as Lybalvi, is a newly FDA approved formulation aimed at attenuating antipsychotic induced weight gain via modulation of the endogenous opioid system with samidorphan, while retaining the robust antipsychotic efficacy of olanzapine. AREAS COVERED: We reviewed the published literature of OLZ/SAM for the management of schizophrenia using the US National Library of Medicine's PubMed.gov resource. Topics covered in this narrative review include the pharmacokinetics, pharmacodynamics, efficacy, and tolerability of OLZ/SAM. EXPERT OPINION: OLZ/SAM is an effective and well-tolerated pharmacologic option in mitigating olanzapine induced weight gain while retaining olanzapine's efficacy. OLZ/SAM cumulatively tends to attenuate weight gain rather than promote weight loss. Effect on metabolic laboratory variables appears limited. Additional research will be needed to determine its effectiveness compared to alternative strategies to attenuate antipsychotic induced weight gain.
Recommended Citation
Faden, J., Serdenes, R., & Citrome, L. (2022). Olanzapine-Samidorphan Combination Tablets for the Treatment of Schizophrenia and Bipolar I Disorder - What Is It, and Will It Be Used?. Expert Review of Neurotherapeutics, 22 (5), 365-376. https://doi.org/10.1080/14737175.2022.2060742