Dynamic Covalent Hydrogel of Natural Product Baicalin With Antibacterial Activities

Authors

Zhen-Zhen Wang, Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China zzwang@hactcm.edu.cn.
Yuan Jia, Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China zzwang@hactcm.edu.cn.
Guoqiang Wang, Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China zzwang@hactcm.edu.cn.
Hongjuan He, Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China zzwang@hactcm.edu.cn.
Lihua Cao, Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China zzwang@hactcm.edu.cn.
Yanmei Shi, Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China zzwang@hactcm.edu.cn.
Mingsan Miao, Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China zzwang@hactcm.edu.cn.
Xiu-Min Li, Department of Pathology, Microbiology & Immunology, New York Medical College Valhalla NY USA XiuMin_Li@NYMC.edu.Follow

Author Type(s)

Faculty

DOI

10.1039/d1ra07553e

Journal Title

RSC Advances

First Page

8737

Last Page

8742

Document Type

Article

Publication Date

3-15-2022

Department

Pathology, Microbiology and Immunology

Abstract

Baicalin has been demonstrated to have multiple pharmacological activities but low solubility. Various baicalin hydrogels have been used to improve its solubility and break its limitation in clinical applications. However, traditional baicalin hydrogels contain numerous ingredients and usually show low baicalin loading capacity. Herein, we discovered a dynamic covalent hydrogel only consisting of baicalin and inorganic borate, in which baicalin is considered as the carrier and drug without other ingredients. The dynamic boronate bonds endow the hydrogel with excellent degradability and multi-stimuli-responsiveness. Moreover, the hydrogel displayed remarkable thixotropy, moldability, and self-healing properties. And the biocompatible baicalin hydrogel exhibited significant antibacterial activities, and can be considered as a potential drug delivery system for biomedical applications.

Recommended Citation

Wang, Z., Jia, Y., Wang, G., He, H., Cao, L., Shi, Y., Miao, M., & Li, X. (2022). Dynamic Covalent Hydrogel of Natural Product Baicalin With Antibacterial Activities. RSC Advances, 12 (14), 8737-8742. https://doi.org/10.1039/d1ra07553e