NYMC Faculty Publications

Inclisiran: Small Interfering Ribonucleic Acid Injectable for the Treatment of Hyperlipidemia

Author Type(s)

Faculty

DOI

10.1097/CRD.0000000000000452

Journal Title

Cardiology in Review

First Page

214

Last Page

219

Document Type

Article

Publication Date

7-1-2022

Department

Medicine

Abstract

Elevated plasma lipid levels, especially low-density lipoprotein, are correlated with atherosclerotic cardiovascular disease (ASCVD) and increased risk of ischemic heart disease and stroke. Statins are first-line agents for reducing low-density lipoprotein cholesterol (LDL-C) and the risk of major cardiovascular events, but patients with a genetic susceptibility or established ASCVD oftentimes remain subtherapeutic on statin therapy alone. Biotechnological advancements in medication therapy have led to the development of inclisiran, a recently approved twice-yearly injectable agent to help patients with heterozygous familial hypercholesterolemia and clinical ASCVD on a maximally tolerated statin to reach LDL-C targets. Inclisiran has demonstrated robust LDL-C reduction in clinical trials in combination with a favorable safety profile; however, the effect on cardiovascular clinical outcomes still remains under evaluation.

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