NYMC Faculty Publications
Oscillators in the Microvasculature: Glycocalyx and Beyond
Author Type(s)
Faculty
DOI
10.1152/ajpcell.00170.2022
Journal Title
American Journal of Physiology. Cell Physiology
First Page
C432
Last Page
C438
Document Type
Article
Publication Date
8-1-2022
Department
Medicine
Abstract
The growing recognition of abundance of oscillating functions in biological systems has motivated this brief overview, which narrows down on the microvasculature. Specifically, it encompasses self-sustained oscillations of blood flow, hematocrit, and viscosity at bifurcations; blood flow effects on the oscillations of endothelial glycocalyx, mechanotransduction, and its termination to prime endothelial cells for the subsequent mechanical signaling event; oscillating affinity of hyaluronan-CD44 binding domain; spontaneous contractility of actomyosin complexes in the cortical actin web and its effects on the tension of the plasma membrane; reversible effects of sirtuin-1 on endothelial glycocalyx; and effects of plasma membrane tension on endo- and exocytosis. Some potential interactions between those oscillators, and their coupling, are discussed together with their transition into chaotic movements. Future in-depth understanding of the oscillatory activities in the microvasculature could serve as a guide to its chronotherapy under pathological conditions.
Recommended Citation
Goligorsky, M. S. (2022). Oscillators in the Microvasculature: Glycocalyx and Beyond. American Journal of Physiology. Cell Physiology, 323 (2), C432-C438. https://doi.org/10.1152/ajpcell.00170.2022