Pharmacologic Weight Management in the Era of Adolescent Obesity

Authors

• Vandana Raman, Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113, USA.
• Anshu Gupta, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia 23219, USA.Follow
• Ambika P. Ashraf, Division of Pediatric Endocrinology & Diabetes, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA.Follow
• Emily Breidbart, Department of Pediatrics, Division Pediatric Endocrinology and Diabetes, NYU Grossman School of Medicine, New York, New York 10016, USA.
• Evgenia Gourgari, Department of Pediatrics, Division of Pediatric Endocrinology, Georgetown University, Washington, District of Columbia 20007, USA.
• Manmohan Kamboj, Division of Pediatric Endocrinology, Nationwide Children's Hospital at The Ohio State University, Columbus, Ohio 43205, USA.
• Brenda Kohn, Department of Pediatrics, Division Pediatric Endocrinology and Diabetes, NYU Grossman School of Medicine, New York, New York 10016, USA.
• Sowmya Krishnan, Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.Follow
• Amit Lahoti, Department of Pediatrics, University of Tennessee Health Sciences Center, Le Bonheur Children's Hospital, Memphis, Tennessee 38163, USA.
• Kristal Matlock, Department of Pediatrics, Division of Pediatric Endocrinology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
• Shilpa Mehta, Department of Pediatrics, Division of Pediatric Endocrinology, New York Medical College, Valhalla, New York 10595, USA.Follow
• Sejal Mistry, Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah 84108, USA.
• Ryan Miller, Department of Pediatrics, University of Maryland School of Medicine , Baltimore, Maryland 21093, USA.Follow
• Laura Page, Department of Pediatrics, Division of Endocrinology, Department of Pediatrics, Duke University, Durham, North Carolina 27710, USA.
• Danielle Reynolds, Diabetes and Endocrinology Center, University of South Florida, Tampa, Florida 33620, USA.
• Joan C. Han, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Author Type(s)

Faculty

DOI

10.1210/clinem/dgac418

Journal Title

The Journal of Clinical Endocrinology and Metabolism

First Page

2716

Last Page

2728

Document Type

Article

Publication Date

9-28-2022

Department

Pediatrics

Keywords

obesity, pediatrics, pharmacotherapy

Disciplines

Medicine and Health Sciences

Abstract

CONTEXT: Pediatric obesity is a serious health problem in the United States. While lifestyle modification therapy with dietary changes and increased physical activity are integral for the prevention and treatment of mild to moderate obesity in youth, only a modest effect on sustained weight reduction is observed in children and young adults with severe obesity. This underscores the need for additional evidence-based interventions for children and adolescents with severe obesity, including pharmacotherapy, before considering invasive procedures such as bariatric surgery. EVIDENCE ACQUISITION: This publication focuses on recent advances in pharmacotherapy of obesity with an emphasis on medications approved for common and rarer monogenic forms of pediatric obesity. EVIDENCE SYNTHESIS: We review medications currently available in the United States, both those approved for weight reduction in children and "off-label" medications that have a broad safety margin. CONCLUSION: It is intended that this review will provide guidance for practicing clinicians and will encourage future exploration for successful pharmacotherapy and other interventions for obesity in youth.

Recommended Citation

Raman, V., Gupta, A., Ashraf, A. P., Breidbart, E., Gourgari, E., Kamboj, M., Kohn, B., Krishnan, S., Lahoti, A., Matlock, K., Mehta, S., Mistry, S., Miller, R., Page, L., Reynolds, D., & Han, J. C. (2022). Pharmacologic Weight Management in the Era of Adolescent Obesity. The Journal of Clinical Endocrinology and Metabolism, 107 (10), 2716-2728. https://doi.org/10.1210/clinem/dgac418