NYMC Faculty Publications
Pharmacologic Weight Management in the Era of Adolescent Obesity
Author Type(s)
Faculty
DOI
10.1210/clinem/dgac418
Journal Title
The Journal of Clinical Endocrinology and Metabolism
First Page
2716
Last Page
2728
Document Type
Article
Publication Date
9-28-2022
Department
Pediatrics
Abstract
CONTEXT: Pediatric obesity is a serious health problem in the United States. While lifestyle modification therapy with dietary changes and increased physical activity are integral for the prevention and treatment of mild to moderate obesity in youth, only a modest effect on sustained weight reduction is observed in children and young adults with severe obesity. This underscores the need for additional evidence-based interventions for children and adolescents with severe obesity, including pharmacotherapy, before considering invasive procedures such as bariatric surgery. EVIDENCE ACQUISITION: This publication focuses on recent advances in pharmacotherapy of obesity with an emphasis on medications approved for common and rarer monogenic forms of pediatric obesity. EVIDENCE SYNTHESIS: We review medications currently available in the United States, both those approved for weight reduction in children and "off-label" medications that have a broad safety margin. CONCLUSION: It is intended that this review will provide guidance for practicing clinicians and will encourage future exploration for successful pharmacotherapy and other interventions for obesity in youth.
Recommended Citation
Raman, V., Gupta, A., Ashraf, A. P., Breidbart, E., Gourgari, E., Kamboj, M., Kohn, B., Krishnan, S., Lahoti, A., Matlock, K., Mehta, S., Mistry, S., Miller, R., Page, L., Reynolds, D., & Han, J. C. (2022). Pharmacologic Weight Management in the Era of Adolescent Obesity. The Journal of Clinical Endocrinology and Metabolism, 107 (10), 2716-2728. https://doi.org/10.1210/clinem/dgac418