Improving Liver Transplant Outcomes for Hepatitis C Virus Hepatocellular Carcinoma in the Direct-Acting Antiviral Therapy Era

Authors

Kenji Okumura, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.
Hiroshi Sogawa, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.
David Samson, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.
Jonathan Butler, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.
Gregory Veillette, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.
Devon John, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.Follow
Thomas Diflo, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.Follow
Roxana Bodin, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.Follow
David C. Wolf, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.
Rifat Latifi, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York.Follow
Seigo Nishida, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, New York. Electronic address: Seigo.Nishida@wmchealth.org.

Author Type(s)

Faculty, Resident/Fellow

DOI

10.1016/j.transproceed.2022.03.070

Journal Title

Transplantation Proceedings

First Page

1834

Last Page

1838

Document Type

Article

Publication Date

9-1-2022

Department

Surgery

Second Department

Medicine

Abstract

BACKGROUND: Direct-acting antiviral (DAA) therapy has transformed the outcomes of liver transplant (LT) with hepatitis C virus (HCV). This study aimed to analyze the effects of DAA treatment for HCV-associated hepatocellular carcinoma (HCC) in LT. METHODS: We included patients confirmed with HCC on explant, analyzed data from United Network for Organ Sharing, and defined the pre-DAA era (2012-2013) and DAA era (2014-2016). RESULTS: HCV-associated HCC cases totaled 4778 (62%) during the study period. In the DAA era, the median recipient age was older and the median days on the waiting list were longer. For the donor, median age, body mass index, and the rate of HCV significantly increased in the DAA era. In pathology, the median largest tumor size was significantly higher; however, the rate of completed tumor necrosis was significant higher in the DAA era. The 3-year graft/patient survival had significantly improved in the DAA era. In multivariable analysis, the DAA era (hazard ratio, 0.79; 95% confidence interval, 0.68-0.91) had significantly affected the 3-year graft survival. CONCLUSIONS: DAA has a significant beneficial effect on LT. In the DAA era, graft survival for HCV-associated HCC has been significantly improving.

Recommended Citation

Okumura, K., Sogawa, H., Samson, D., Butler, J., Veillette, G., John, D., Diflo, T., Bodin, R., Wolf, D. C., Latifi, R., & Nishida, S. (2022). Improving Liver Transplant Outcomes for Hepatitis C Virus Hepatocellular Carcinoma in the Direct-Acting Antiviral Therapy Era. Transplantation Proceedings, 54 (7), 1834-1838. https://doi.org/10.1016/j.transproceed.2022.03.070