NYMC Faculty Publications
Interactome of Long Non-Coding RNAs: Transcriptomic Expression Patterns and Shaping Cancer Cell Phenotypes
Author Type(s)
Faculty
DOI
10.3390/ijms24129914
Journal Title
International Journal of Molecular Sciences
Document Type
Article
Publication Date
6-8-2023
Department
Pathology, Microbiology and Immunology
Abstract
RNA biology has gained extensive recognition in the last two decades due to the identification of novel transcriptomic elements and molecular functions. Cancer arises, in part, due to the accumulation of mutations that greatly contribute to genomic instability. However, the identification of differential gene expression patterns of wild-type loci has exceeded the boundaries of mutational study and has significantly contributed to the identification of molecular mechanisms that drive carcinogenic transformation. Non-coding RNA molecules have provided a novel avenue of exploration, providing additional routes for evaluating genomic and epigenomic regulation. Of particular focus, long non-coding RNA molecule expression has been demonstrated to govern and direct cellular activity, thus evidencing a correlation between aberrant long non-coding RNA expression and the pathological transformation of cells. lncRNA classification, structure, function, and therapeutic utilization have expanded cancer studies and molecular targeting, and understanding the lncRNA interactome aids in defining the unique transcriptomic signatures of cancer cell phenotypes.
Recommended Citation
DeSouza, N. R., Quaranto, D., Carnazza, M., Jarboe, T., Tiwari, R. K., & Geliebter, J. (2023). Interactome of Long Non-Coding RNAs: Transcriptomic Expression Patterns and Shaping Cancer Cell Phenotypes. International Journal of Molecular Sciences, 24 (12). https://doi.org/10.3390/ijms24129914