NYMC Faculty Publications
Recent Developments on the Vascular Effects of 20-hydroxyeicosatetraenoic Acid
DOI
10.1097/MNH.0000000000000302
Journal Title
Current Opinion in Nephrology and Hypertension
First Page
74
Last Page
82
Document Type
Article
Publication Date
3-1-2017
Department
Pharmacology
Abstract
PURPOSE OF REVIEW: 20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid and a key constituent of the microcirculation. Its effects on vascular function are multifaceted and include stimulation of smooth muscle, contractility, migration, and proliferation, as well as endothelial cell dysfunction and inflammation. Such effects have significant implications with regard to the control of vascular homeostasis and pathophysiology. The clinical relevance of 20-HETE is highlighted by recent studies linking 20-HETE and its biosynthetic enzymes to the development of hypertension, stroke, and myocardial infarction. RECENT FINDINGS: This article presents past and recent findings that focus on the role of 20-HETE in the regulation of the vasculature in health and disease and the implication of its actions on endothelial and vascular smooth muscle cells to the pathogenesis of hypertension and stroke. SUMMARY: To date clinical studies corroborated animal studies in that they place 20-HETE as a significant contributor to the pathogenesis of cardiovascular diseases. Consequently, uncovering 20-HETE effects in the vasculature along with understanding its mechanism of action provide a strong basis for the development of novel therapeutic strategies to prevent vascular/end organ damage in these diseases.
Recommended Citation
Garcia, V., & Schwartzman, M. (2017). Recent Developments on the Vascular Effects of 20-hydroxyeicosatetraenoic Acid. Current Opinion in Nephrology and Hypertension, 26 (2), 74-82. https://doi.org/10.1097/MNH.0000000000000302