NYMC Faculty Publications

CAR T Cell Therapy for T Cell Leukemia and Lymphoma: Latest Updates From 2022 ASH Annual Meeting

Author Type(s)

Faculty

DOI

10.1186/s13045-023-01406-8

Journal Title

Journal of Hematology & Oncology

First Page

18

Document Type

Article

Publication Date

3-5-2023

Department

Medicine

Abstract

Due to the concern of fratricide, clinical development of CAR T cells for the therapy of T cell malignancies lags behind that for B cell malignancies. Attempts are being made to revise T cell biomarkers so that the re-engineered CAR T cells can target T cell malignancies. CD3 and CD7 are the two pan-T cell surface biomarkers that have been either knocked out or knocked down through genome base- editing technology or by protein expression blockers so that the re-engineered T cells can target T cells without fratricide. We summarized several latest reports on the CAR T cells for the therapy of T cell leukemia /lymphoma from the 2022 ASH Annual Meeting, with latest updates on clinical trials of TvT CAR7, RD-13-01, and CD7 CART.

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