CAR T Cell Therapy for T Cell Leukemia and Lymphoma: Latest Updates From 2022 ASH Annual Meeting
Due to the concern of fratricide, clinical development of CAR T cells for the therapy of T cell malignancies lags behind that for B cell malignancies. Attempts are being made to revise T cell biomarkers so that the re-engineered CAR T cells can target T cell malignancies. CD3 and CD7 are the two pan-T cell surface biomarkers that have been either knocked out or knocked down through genome base- editing technology or by protein expression blockers so that the re-engineered T cells can target T cells without fratricide. We summarized several latest reports on the CAR T cells for the therapy of T cell leukemia /lymphoma from the 2022 ASH Annual Meeting, with latest updates on clinical trials of TvT CAR7, RD-13-01, and CD7 CART.
Huang, Q., Zhang, X., & Liu, D. (2023). CAR T Cell Therapy for T Cell Leukemia and Lymphoma: Latest Updates From 2022 ASH Annual Meeting. https://doi.org/10.1186/s13045-023-01406-8