Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
BACKGROUND: Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients. METHODS: We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity. RESULTS: Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval, .78-2.15; P = .32). CONCLUSIONS: Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19.
Halasa, N. B., Spieker, A. J., Young, C. C., Olson, S. M., Newhams, M. M., Amarin, J. Z., Moffitt, K. L., Nakamura, M. M., Levy, E. R., Soma, V. L., Talj, R., Weiss, S. L., Fitzgerald, J. C., Mack, E. H., Maddux, A. B., Schuster, J. E., Coates, B. M., Hall, M. W., Schwartz, S. P., Schwarz, A. J., Kong, M., Spinella, P. C., Loftis, L. L., McLaughlin, G. E., Hobbs, C. V., Rowan, C. M., Bembea, M. M., Nofziger, R. A., Babbitt, C. J., Bowens, C., Flori, H. R., & Gertz, S. J. (2023). Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. https://doi.org/10.1093/cid/ciac477