Seafood Allergy: Allergen, Epitope Mapping and Immunotherapy Strategy

Authors

Ziye Zhang, Laboratory of Food Safety, College of Food Science and Engineering, Ocean University of China, Qingdao, China.
Xiu-Min Li, Department of Pathology, Microbiology and Immunology and Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, New York, USA.Follow
Hao Wang, Laboratory of Food Safety, College of Food Science and Engineering, Ocean University of China, Qingdao, China.
Hong Lin, Laboratory of Food Safety, College of Food Science and Engineering, Ocean University of China, Qingdao, China.
Hang Xiao, Department of Food Science, University of Massachusetts, Amherst, Massachusetts, USA.
Zhenxing Li, Laboratory of Food Safety, College of Food Science and Engineering, Ocean University of China, Qingdao, China.

Author Type(s)

Faculty

DOI

10.1080/10408398.2023.2181755

Journal Title

Critical Reviews in Food Science and Nutrition

First Page

1314

Last Page

1338

Document Type

Article

Publication Date

1-1-2023

Department

Pathology, Microbiology and Immunology

Abstract

Seafoods are fashionable delicacies with high nutritional values and culinary properties, while seafood belongs to worldwide common food allergens. In recent years, many seafood allergens have been identified, while the diversity of various seafood species give a great challenge in identifying and characterizing seafood allergens, mapping IgE-binding epitopes and allergen immunotherapy development, which are critical for allergy diagnostics and immunotherapy treatments. This paper reviewed the recent progress on seafood (fish, crustacean, and mollusk) allergens, IgE-binding epitopes and allergen immunotherapy for seafood allergy. In recent years, many newly identified seafood allergens were reported, this work concluded the current situation of seafood allergen identification and designation by the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) Allergen Nomenclature Sub-Committee. Moreover, this review represented the recent advances in identifying the IgE-binding epitopes of seafood allergens, which were helpful to the diagnosis, prevention and treatment for seafood allergy. Furthermore, the allergen immunotherapy could alleviate seafood allergy and provide promising approaches for seafood allergy treatment. This review represents the recent advances and future outlook on seafood allergen identification, IgE-binding epitope mapping and allergen immunotherapy strategies for seafood allergy prevention and treatment.

Recommended Citation

Zhang, Z., Li, X., Wang, H., Lin, H., Xiao, H., & Li, Z. (2023). Seafood Allergy: Allergen, Epitope Mapping and Immunotherapy Strategy. Critical Reviews in Food Science and Nutrition, 63 (10), 1314-1338. https://doi.org/10.1080/10408398.2023.2181755