Schizophrenia: One Name, Many Different Manifestations

Authors

Justin Faden, Lewis Katz School of Medicine at Temple University, 100 East Lehigh Avenue, Suite 305B, Philadelphia, PA 19125, USA. Electronic address: Justin.Faden@tuhs.temple.edu.
Leslie Citrome, New York Medical College, Valhalla, NY, USA.

Author Type(s)

Faculty

DOI

10.1016/j.mcna.2022.05.005

Journal Title

The Medical Clinics of North America

First Page

61

Last Page

72

Document Type

Article

Publication Date

1-1-2023

Department

Psychiatry and Behavioral Sciences

Abstract

Schizophrenia is a disabling condition impacting approximately 1% of the worldwide population. Symptoms include positive symptoms (eg, hallucinations, delusions), negative symptoms (eg, avolition, anhedonia), and cognitive impairment. There are likely many different environmental and pathophysiologic etiologies involving distinct neurotransmitters and neurocircuits. Pharmacologic treatment at present consists of dopamine receptor antagonists, which are reasonably effective at treating positive symptoms, but less effective at treating cognitive and negative symptoms. Nondopaminergic medications targeting alternative receptors are under investigation. Supportive psychosocial treatments can work in tandem with antipsychotic medications and optimize patient care.

Recommended Citation

Faden, J., & Citrome, L. (2023). Schizophrenia: One Name, Many Different Manifestations. The Medical Clinics of North America, 107 (1), 61-72. https://doi.org/10.1016/j.mcna.2022.05.005