Cardiovascular Manifestations of Systemic Sclerosis: An Overview of Pathophysiology, Screening Modalities, and Treatment Options

Authors

Kyu-In Lee, From the Department of Medicine, Westchester Medical Center, Valhalla, NY.
Levy Jo Manuntag, From the Department of Medicine, Westchester Medical Center, Valhalla, NY.
Alina Kifayat, Department of Rheumatology, Westchester Medical Center/New York Medical College, Valhalla, NY.Follow
Samantha Eugene Manuntag, Department of Medicine, University of Nevada, Reno, NV.
Kirk Sperber, Department of Rheumatology, Westchester Medical Center/New York Medical College, Valhalla, NY.
Julia Yegudin Ash, Department of Rheumatology, Westchester Medical Center/New York Medical College, Valhalla, NY.Follow
William H. Frishman, Department of Allergy/Immunology, Westchester Medical Center/New York Medical College, Valhalla, NY.
Amy Wasserman, Department of Rheumatology, Westchester Medical Center/New York Medical College, Valhalla, NY.

Author Type(s)

Faculty

DOI

10.1097/CRD.0000000000000420

Journal Title

Cardiology in Review

First Page

22

Last Page

27

Document Type

Article

Publication Date

1-1-2023

Department

Medicine

Abstract

Systemic sclerosis, previously known as scleroderma, is a heterogeneous, systemic disease that is defined by its 3 pathological hallmarks: the production of autoantibodies, small vessel vasculopathy, and fibroblast dysfunction, leading to an increased deposition of extracellular matrix. We conducted a review of the available literature that covers the cardiovascular manifestations of SSc: electrical conduction abnormalities, pulmonary hypertension, pericardial disease, and atherosclerosis. Within each major category, we will discuss the definition, diagnostics, and available treatment options. Increased mortality from cardiovascular complications necessitates early screening and management. Annual screening with noninvasive modalities is encouraged. The current management of each complication generally follows the management algorithms of patients regardless of SSc status and is dependent on the severity of the patient's clinical presentation.

Recommended Citation

Lee, K., Manuntag, L. J., Kifayat, A., Manuntag, S. E., Sperber, K., Ash, J. Y., Frishman, W. H., & Wasserman, A. (2023). Cardiovascular Manifestations of Systemic Sclerosis: An Overview of Pathophysiology, Screening Modalities, and Treatment Options. Cardiology in Review, 31 (1), 22-27. https://doi.org/10.1097/CRD.0000000000000420