NYMC Faculty Publications
Significant Mortality Associated With COVID-19 and Comorbid Cerebrovascular Disease: A Quantitative Systematic Review
Author Type(s)
Faculty, Student, Resident/Fellow
DOI
10.1097/CRD.0000000000000480
Journal Title
Cardiology in Review
First Page
199
Last Page
206
Document Type
Article
Publication Date
7-1-2023
Department
Neurosurgery
Second Department
Pediatrics
Third Department
Radiology
Abstract
We report the first quantitative systematic review of cerebrovascular disease in coronavirus disease 2019 (COVID-19) to provide occurrence rates and associated mortality. Through a comprehensive search of PubMed we identified 8 cohort studies, 5 case series, and 2 case reports of acute cerebrovascular disease in patients with confirmed COVID-19 diagnosis. Our first meta-analysis utilizing the identified publications focused on comorbid cerebrovascular disease in recovered and deceased patients with COVID-19. We performed 3 additional meta-analyses of proportions to produce point estimates of the mortality and incidence of acute cerebrovascular disease in COVID-19 patients. Patient's with COVID-19 who died were 12.6 times more likely to have a history of cerebrovascular disease. We estimated an occurrence rate of 2.6% (95% confidence interval, 1.2-5.4%) for acute cerebrovascular disease among consecutively admitted patients with COVID-19. While for those with severe COVID-19' we estimated an occurrence rate of 6.5% (95% confidence interval, 4.4-9.6%). Our analysis estimated a rate of 35.5% for in-hospital mortality among COVID-19 patients with concomitant acute cerebrovascular disease. This was consistent with a mortality rate of 34.0% which we obtained through an individual patient analysis of 47 patients derived from all available case reports and case series. COVID-19 patients with either acute or chronic cerebrovascular disease have a high mortality rate with higher occurrence of cerebrovascular disease in patients with severe COVID-19.
Recommended Citation
Sursal, T., Gandhi, C. D., Clare, K., Feldstein, E., Frid, I., Kefina, M., Galluzzo, D., Kamal, H., Nuoman, R., Amuluru, K., Muh, C. R., Pisapia, J. M., Gulko, E., Overby, P., Chandy, D., Etienne, M., Kurian, C., Kaur, G., Dakay, K., AlHamid, M., Al-Jehani, H., Mayer, S. A., & Al-Mufti, F. (2023). Significant Mortality Associated With COVID-19 and Comorbid Cerebrovascular Disease: A Quantitative Systematic Review. Cardiology in Review, 31 (4), 199-206. https://doi.org/10.1097/CRD.0000000000000480