Outcomes of Combined Heart and Kidney Transplantation Under the New Heart Allocation Policy: A United Organ Network for Organ Sharing Database Analysis

Authors

Suguru Ohira, Division of Cardiothoracic Surgery, Department of Surgery (S.O., K.O., C.B.D.L.P., D.S., M.K.), New York Medical College, Valhalla.Follow
Kenji Okumura, Division of Cardiothoracic Surgery, Department of Surgery (S.O., K.O., C.B.D.L.P., D.S., M.K.), New York Medical College, Valhalla.
Stephen Pan, Department of Cardiology (S.P., E.L.), New York Medical College, Valhalla.Follow
Abhay Dhand, Transplant Infectious Disease, Department of Medicine and Surgery (A.D.), New York Medical College, Valhalla.Follow
Elliot Levine, Department of Cardiology (S.P., E.L.), New York Medical College, Valhalla.Follow
Corazon B. De La Pena, Division of Cardiothoracic Surgery, Department of Surgery (S.O., K.O., C.B.D.L.P., D.S., M.K.), New York Medical College, Valhalla.
Seigo Nishida, Division of Abdominal Transplant Surgery, Department of Surgery, Westchester Medical Center (S.N.), New York Medical College, Valhalla.
David Spielvogel, Division of Cardiothoracic Surgery, Department of Surgery (S.O., K.O., C.B.D.L.P., D.S., M.K.), New York Medical College, Valhalla.
Masashi Kai, Division of Cardiothoracic Surgery, Department of Surgery (S.O., K.O., C.B.D.L.P., D.S., M.K.), New York Medical College, Valhalla.Follow

Author Type(s)

Resident/Fellow, Faculty

DOI

10.1161/CIRCHEARTFAILURE.122.010059

Journal Title

Circulation. Heart Failure

First Page

e010059

Document Type

Article

Publication Date

4-1-2023

Department

Surgery

Second Department

Medicine

Abstract

BACKGROUND: The impact of the new heart allocation policy, which prioritizes acutely ill patients on temporary mechanical circulatory support and provides broader sharing of donor organs, on patient and graft survival in combined heart and kidney transplantation (HKT) is unknown. METHODS: In the United Network for Organ Sharing data, patients were divided in groups before and after the policy change (OLD, January 1, 2015 to October 17, 2018, N=533; and NEW, October 18, 2018 to December 31, 2020, N=370). Propensity score matching was performed utilizing recipient characteristics (283 pairs). The median follow-up was 1099 days. RESULTS: The annual volume of HKT increased approximately 2-fold during this period (N=117 in 2015 and N=237 in 2020), predominantly among patients not on hemodialysis at time of transplantation. Ischemic times for heart (OLD, 2.94 versus NEW, 3.37 hours; <0.001) and kidney grafts (14.1 versus 16.0 hours; <0.001) were longer under the new policy, as was the travel distance (47 versus 183 miles; <0.001). In the matched cohort, 1-year overall survival (OLD, 91.1% versus NEW, 84.8%; <0.001), and freedom from heart and kidney graft failure rate were worse under the new policy. Patients not on hemodialysis at time of HKT demonstrated worse survival and a higher risk of kidney graft failure under the new policy compared with the old policy. In multivariate Cox proportional-hazards analysis, the new policy was associated with an increased risk of mortality (hazard ratio, 1.81; =0.007), and graft failure among HKT recipients (heart, hazard ratio, 1.81; =0.007; and kidney, hazard ratio, 1.83; =0.002). CONCLUSIONS: The new heart allocation policy was associated with worse overall survival and decreased freedom from heart and kidney graft failure in HKT recipients.

Recommended Citation

Ohira, S., Okumura, K., Pan, S., Dhand, A., Levine, E., De La Pena, C. B., Nishida, S., Spielvogel, D., & Kai, M. (2023). Outcomes of Combined Heart and Kidney Transplantation Under the New Heart Allocation Policy: A United Organ Network for Organ Sharing Database Analysis. Circulation. Heart Failure, 16 (4), e010059. https://doi.org/10.1161/CIRCHEARTFAILURE.122.010059