NYMC Faculty Publications

Acute Respiratory Distress Syndrome in Patients With Subarachnoid Hemorrhage: Incidence, Predictive Factors, and Impact on Mortality

Eric Feldstein, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Syed Ali, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.Follow
Smit Patel, UCLA Medical Center, Los Angeles, CA, USA.Follow
Keshav Raghavendran, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Erick Martinez, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Leah Blowes, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Jonathan Ogulnick, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Michelle Bravo, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Jose Dominguez, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Boyi Li, University of North Carolina, Chapel Hill, NC, USA.
Ogaga Urhie, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Jon Rosenberg, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Christian Bowers, 12288University of New Mexico, Albuquerque, NM, USA.
Kartik Prabhakaran, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.Follow
Andrew Bauershmidt, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
Stephan A. Mayer, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.Follow
Chirag D. Gandhi, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.Follow
Fawaz Al-Mufti, 8137Westchester Medical Center/New York Medical College, Valhalla, NY, USA.Follow

Author Type(s)

Resident/Fellow, Faculty

DOI

10.1177/15910199221082457

Journal Title

Interventional Neuroradiology

First Page

189

Last Page

195

Document Type

Article

Publication Date

4-1-2023

Department

Neurosurgery

Second Department

Neurology

Third Department

Surgery

Abstract

INTRODUCTION: Acute respiratory distress syndrome (ARDS) is a known predictor of poor outcomes in critically ill patients. We sought to examine the role ARDS plays in outcomes in subarachnoid hemorrhage (SAH) patients. Prior studies investigating the incidence of ARDS in SAH patients did not control for SAH severity. Hence, we sought to determine the incidence ARDS in patients diagnosed with aneurysmal SAH and investigate the predisposing risk factors and impact upon outcomes. METHODS: A retrospective cohort study was conducted using the National Inpatient Sample (NIS) database for the years 2008 to 2014. Multivariate stepwise regression analysis was performed to identify the risk factors and outcome associated with developing ARDS in the setting of SAH. RESULTS: We identified 170,869 patients with non-traumatic subarachnoid hemorrhage, of whom 6962 were diagnosed with ARDS and of those 4829 required mechanical ventilation. ARDS more frequently developed in high grade SAH patients (1.97 ± 0.05 vs. 1.15 ± 0.01; p < 0.0001). Neurologic predictors of ARDS included cerebral edema (OR 1.892, CI 1.180-3.034, p = 0.0035) and medical predictors included cardiac arrest (OR 4.642, CI 2.273-9.482, p < 0.0001) and cardiogenic shock (OR 2.984, CI 1.157-7.696, p = 0.0239). ARDS was associated with significantly worse outcomes (15.5% vs. 52.9% discharged home, 63.0% vs. 40.8% discharged to rehabilitation facility and 21.5% vs. 6.3% in-hospital mortality). CONCLUSION: Patients with SAH who developed ARDS were less likely to be discharged home, more likely to need rehabilitation and had a significantly higher risk of mortality. The identification of risk factors contributing to ARDS is helpful for improving outcomes and resource utilization.

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