Utility of Frailty as a Predictor of Acute Kidney Injury in Patients With Aneurysmal Subarachnoid Hemorrhage

Authors

Christina Ng, 200540School of Medicine, 8137New York Medical College, Valhalla, NY, USA.
Jose F. Dominguez, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.
Rasheed Hosein-Woodley, 200540School of Medicine, 8137New York Medical College, Valhalla, NY, USA.
Eric Feldstein, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.
Alexandria Naftchi, 200540School of Medicine, 8137New York Medical College, Valhalla, NY, USA.
Aiden Lui, 200540School of Medicine, 8137New York Medical College, Valhalla, NY, USA.
Alis J. Dicpinigaitis, 200540School of Medicine, 8137New York Medical College, Valhalla, NY, USA.
Matthew K. McIntyre, Department of Neurological Surgery, 89020Oregon Health & Science University, Portland, OR, USA.
Gurmeen Kaur, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.
Justin Santarelli, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.
Andrew Bauerschmidt, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.Follow
Stephan A. Mayer, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.Follow
Christian A. Bowers, Department of Neurosurgery, 12288University of New Mexico School of Medicine, Albuquerque, NM, USA.
Chirag D. Gandhi, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.Follow
Fawaz Al-Mufti, Department of Neurosurgery, 8138Westchester Medical Center and New York Medical College, Valhalla, NY, USA.Follow

Author Type(s)

Resident/Fellow, Student, Faculty

DOI

10.1177/15910199221076626

Journal Title

Interventional Neuroradiology

First Page

114

Last Page

120

Document Type

Article

Publication Date

2-1-2023

Department

Neurosurgery

Second Department

Neurology

Abstract

INTRODUCTION: Acute kidney injury (AKI) is associated with poor outcome in aneurysmal subarachnoid hemorrhage patients (aSAH). Frailty has recently been demonstrated to correlate with elevated mortality and morbidity; its impact on predicting AKI and mortality in aSAH patients has not been investigated. OBJECTIVE: Evaluating risk factors and predictors for AKI in aSAH patients. METHODS: aSAH patients from a single-center's prospectively maintained database were retrospectively evaluated for development of AKI within 14 days of admission. Baseline demographic and clinical characteristics were collected. The effect of frailty and other risk factors were evaluated. RESULTS: Of 213 aSAH patients, 53 (33.1%) were frail and 12 (5.6%) developed AKI. Admission serum creatinine (sCr) and peak sCr within 48 h were higher in frail patients. AKI patients showed a trend towards higher frailty. Mortality was significantly higher in AKI than non-AKI aSAH patients. Frailty was a poor predictor of AKI when controlling for Hunt and Hess (HH) grade or age. HH grade ≥ 4 strongly predicted AKI when controlling for frailty. CONCLUSION: AKI in aSAH patients carries a poor prognosis. The HH grade appears to have superior utility as a predictor of AKI in aSAH patients than mFI.

Recommended Citation

Ng, C., Dominguez, J. F., Hosein-Woodley, R., Feldstein, E., Naftchi, A., Lui, A., Dicpinigaitis, A. J., McIntyre, M. K., Kaur, G., Santarelli, J., Bauerschmidt, A., Mayer, S. A., Bowers, C. A., Gandhi, C. D., & Al-Mufti, F. (2023). Utility of Frailty as a Predictor of Acute Kidney Injury in Patients With Aneurysmal Subarachnoid Hemorrhage. Interventional Neuroradiology, 29 (1), 114-120. https://doi.org/10.1177/15910199221076626