NYMC Faculty Publications
A Case of Disappearing Amyloid on Technetium Pyrophosphate Scan
Author Type(s)
Resident/Fellow, Faculty
Journal Title
Journal of Nuclear Cardiology
First Page
1986
Last Page
1991
Document Type
Article
Publication Date
10-1-2023
Department
Pathology, Microbiology and Immunology
Second Department
Medicine
Abstract
Technetium-99mm pyrophosphate (Tc-PYP) scintigraphy is a highly accurate non-invasive method for the diagnosis of transthyretin (ATTR) cardiac amyloidosis. Prognosis for this disease is improved following treatment with the transthyretin (TTR) stabilizer tafamidis. Although tafamidis slows disease progression, its effects on myocardial amyloid and Tc-PYP uptake remain unclear. We present a patient with ATTR cardiac amyloidosis who had a strongly positive initial Tc-PYP scan, with a dramatic decrease in Tc-PYP uptake on repeat scan after 3 years of tafamidis treatment. However, myocardial biopsy showed persistent diffuse amyloid deposits. This case highlights the need for further studies regarding the utility of serial Tc-PYP scans in monitoring the progress of ATTR cardiomyopathy.
Recommended Citation
Wang, A., Mahmood, U., Tang, X., Jain, D., & Pan, S. (2023). A Case of Disappearing Amyloid on Technetium Pyrophosphate Scan. Journal of Nuclear Cardiology, 30 (5), 1986-1991. https://doi.org/10.1007/s12350-023-03316-1
