NYMC Faculty Publications
Long-Acting Injectable Antipsychotics: What, When, and How
Author Type(s)
Faculty
DOI
10.1017/S1092852921000249
Journal Title
CNS Spectrums
First Page
118
Last Page
129
Document Type
Article
Publication Date
4-2021
Department
Psychiatry and Behavioral Sciences
Abstract
Current guidelines for the treatment of patients with schizophrenia advocate that patients receive treatment with a long-acting injectable (LAI) antipsychotic medication if they prefer such treatment or if they have a history of poor or uncertain adherence. Available LAI formulations in the United States include first-generation antipsychotics (fluphenazine decanoate and haloperidol decanoate), risperidone/paliperidone containing products (risperidone microspheres, paliperidone palmitate, and risperidone subcutaneous), aripiprazole containing products (aripiprazole monohydrate and aripiprazole lauroxil), and olanzapine pamoate. LAI antipsychotics can address the guesswork about adherence status and patients may prefer them if they are offered this as a choice, including individuals early in their disease course. Additional approved indications in the United States for LAI antipsychotics include bipolar I disorder maintenance treatment for risperidone microspheres and aripiprazole monohydrate, and schizoaffective disorder for paliperidone palmitate once monthly. Differences and similarities among the different products are discussed, including guidance regarding optimal treatment selection. Tips are provided to enhance effective patient communication to maximize the likelihood of acceptance of this treatment modality.
Recommended Citation
Citrome, L. (2021). Long-Acting Injectable Antipsychotics: What, When, and How. CNS Spectrums, 26 (2), 118-129. https://doi.org/10.1017/S1092852921000249