NYMC Faculty Publications

Sensitive Acetaminophen Electrochemical Sensor With Amplified Signal Strategy via Non-Covalent Functionalization of Soluble Tetrahydroxyphthalocyanine and Graphene

Author Type(s)

Faculty

DOI

10.1016/j.microc.2020.105609

Journal Title

Microchemical Journal

First Page

105609

Last Page

105609

Document Type

Article

Publication Date

1-2021

Department

Pathology, Microbiology and Immunology

Abstract

A new amplified signal strategy for acetaminophen (AC) electrochemical sensor was explored by soluble zinc tetrahydroxyphthalocyanine-reduced graphene oxide nanocomposite as an improved electrode material via non-covalent functionalization. The electrochemical signal of AC was amplified by the remarkably increased electroactive surface area of the nanocomposite-modified glassy carbon electrode. Moreover, the synergistic enrichment effect can be achieved by the adsorption of π-π stacking and hydrogen bonding of hydroxyl groups. The prominent electrocatalytic effect toward AC oxidation were examined systematically on the proposed sensor and a sensitive and selective electroanalytical method for AC was developed. Under optimized conditions, the electrochemical response of the sensor exhibited a linear dependence on the concentration of AC ranging from 0.03 to 100 μM and 100 to 800 μM with a detection limit of 10 nM (S/N = 3). The proposed sensor with excellent selectivity, reproducibility and long-term stability for AC sensing was successfully applied for AC determination in drug formulation and human urine samples.

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